OUR RESEARCH
1. Bioenergy production
2. Biochemical production
3. Fundamental research
More InfoWelcome to Biochemical Engineering Lab
175 Cho Rong Lee, Changman Kim, Young Eun Song, Hyeonsung Im, You-Kwan Oh, Sunghoon Park, Jung Rae Kim, 2018.07
“Co-culture-based biological carbon monoxide conversion by Citrobacter amalonaticus Y19 and Sporomusa ovata via a reducing-equivalent transfer mediator”
BIORESOURCE TECHNOLOGY, Vol259, 128-135
174 JooYeon Seok, Jina Yang, SangJin, Choi, HyunGyu Lim, UnJong Choi, Kyungjin Kim, SungHoon Park, TaeHyeon Yoo, GyooYeol Jung, 2018.05
“Directed evolution of the 3-hydroxypropionic acid production pathway by engineering aldehyde dehydrogenase using a synthetic selection device”
METABOLIC ENGINEERING, Vol43, P113-120
173 Myung Hyun Noh, Hyun Gyu Lim, Sunghoon Park*, Sang Woo Seo, Gyoo Yeol Jung, 2017.09
“Precise flux redistribution to glyoxylate cycle for 5-aminolevulinic acid production in Escherichia coli”
METABOLIC ENGINEERING, Vol43, P1096-7176
172 Vinod Kumar, Sunghoon Park*
“Potential and limitations of Klebsiella pneumoniae as a microbial cell factory utilizing glycerol as the carbon source”
Biotechnology Advances, in press, P18
171 Yeounjoo Ko, Eunhee Seol, Balaji Sundara Sekar, Seongjin Kwon, Jaehyeon Lee, Sunghoon Park*
“Metabolic engineering of Klebsiella pneumoniae J2B for co-production of 3-hydroxypropionic acid and 1,3-propanediol from glycerol: Reduction of acetate and other by-products”
ELSEVIER SCI LTD, Vol 255, P1096-1103
170 Mugesh Sankaranarayanan, Ashok Somasundar, Eunhee Seol, Ashish Singh Chauhan, Seongjin Kwon, Gyoo Yeol Jung, Sunghoon Park*, 2017
“Production of 3-hydroxypropionic acid by balancing the pathway enzymes using synthetic cassette architecture”
Journal of Biotechnology, In press, P342
169 Suman Lama, Eunhee Seol, Sunghoon Park*, 2017
“Metabolic engineering of Klebsiella pneumoniae J2B for the production of 1,3-propanediol from glucose”
BIoresource Technology, In Press, P1-9
168 Hyeoncheol Francis Son, Sunghoon Park*, Tae Hyean Yoo, Gyoo Yeol Jung, Kyung-Jin Kim, 2017
“Structural insights into the production of 3-hydroxypropionic acid by aldehyde dehydrogenase from Azospirillum brasilense”
Scientific Reports , Vol 7 , P1-10
167 Balaji Sundara Sekar, Eunhee Seol, Sunghoon Park*, 2017
“Co-production of hydrogen and ethanol from glucose in Escherichia coli by activation of pentose-phosphate pathway through deletion of phosphoglucose isomerase (pgi) and overexpression of glucose-6-phosphate dehydrogenase (zwf) and 6-phosphogluconate dehydrogenase (gnd)”
Biotechnol Biofuels , Vol 10 P1-12
166 Satish Kumar Ainala, Eunhee Seol, Jung Rae Kim and Sunghoon Park*, 2017
“Citrobacter amalonaticus Y19 for constitutive expression of carbon monoxide-dependent hydrogen-production machinery”
Biotechnol Biofuels , Vol 10 P1-11
165 Mugesh Sankaranarayanan, Eunhee Seol, Yeonhee Kim, Ashish Singh Chauhan,
Sunghoon Park*, 2017
“Measurement of crude-cell-extract glycerol dehydratase activity in recombinant Escherichia coli using coupled-enzyme reactions”
Journal of Industrial Microbiology & Biotechnology, Vol44, P 477–488
164 Eul-Soo Park, Sunghoon Park*, Jong-Shik Shin, 2017
“Spectrophotometric assay for sensitive detection of glycerol dehydratase activity using aldehyde dehydrogenase”
Journal of Bioscience and Bioengineering, Vol123, P528–533
163 Yeounjoo Ko, Eunhee Seol, Balaji Sundara Sekar, Seongjin Kwon, Jaehyeon Lee, and Sunghoon Park*, 2016
“Evaluation of Newly Isolated Klebsiella pneumoniae Strains for the CoProduction of 3-hydroxypropionic acid and 1,3-propanediol from Glycerol”
KSBB Journal, Vol4, P246-255
162 Zhengbin Li, Soo Moon Ro, Balaji Sundara Sekar, Eunhee Seol, Suman Lama, Sun Gu Lee, Guangyi Wang, Sunghoon Park*, 2016
“Improvement of 1,3-propanedioloxidoreductase (DhaT) stability against 3-hydroxypropionaldehyde by substitution of cysteine residues”
Biotechnology and Bioprocess Engineering, Volume 21,P695–703
161 Changman Kim, Satish Kumar Ainala, You-Kwan Oh, Byong-Hun Jeon, Sunghoon Park and
Jung Rae Kim*, 2016
“Metabolic Flux Change in Klebsiella pneumoniae L17 by Anaerobic Respiration in Microbial Fuel Cell ”
Biotechnology and Bioprocess Engineering, Vol.21, P.250-260
160 Hyun Gyu Lim, Myung Hyun Noh, Jun Hong Jeong, Sunghoon Park* and Gyoo Yeol Jung*, 2016
“Optimum Rebalancing of the 3 Hydroxypropionic Acid Production Pathway from Glycerol in Escherichia coli”
American Chemical Society (ACS), Synthetic Biology
159 Vinod Kumar, Meetu Durgapal, Mugesh Sankaranarayanan, Ashok Somasundar, Chelladurai Rathnasingh, HyoHak Song, Doyoung Seung, Sunghoon Park*, 2016
“Effects of mutation of 2,3-butanediol formation pathway on glycerol metabolism and 1,3-propanediol production by Klebsiella pneumoniae J2B”
Bioresource Technology, Vol.214, P.432–440
158 Balaji Sundara Sekar, Eunhee Seol, Subramanian Mohan Raj and Sunghoon Park*, 2016
“Co-production of hydrogen and ethanol by pfkA-eficient Escherichia coli with activated pentose-phosphate pathway: reduction of pyruvate accumulation”
Biotechnology for Biofuels, Vol.9, P.1-11
157 Eunhee Seol, Balaji Sundara Sekar, Mohan Raj, Sunghoon Park *, 2016
“Co-production of hydrogen and ethanol from glucose by modification glycolytic pathways in Escherichia coli from Embden-Meyerhof-Pamas pathway to pentose phosphate pathway”
Biotechnology Journal, Vol.11, P.1-8
156 Satish Kumar Ainala, Eunhee Seol, Jung Rae Kim, Sunghoon Park*, 2016
“Effect of culture medium on fermentative and CO-dependent H2 production activity in Citrobacter amalonaticus Y19”
International Journal of Hydrogen energy, Vol.41, P.6734-6742
155 Suma Lama, Su Moon Ro, Eunhee Seol, Balaji Sundara Sekar, Satish Kumar Ainala, Jayaraman, Thangappan,. Hyohak Song, Doyoung Seung, and Sunghoon Park*, 2015
“Characterization of 1,3-Propanediol Oxidoreductase(DhaT) from Klebsiella pneumonia J2B” Biotechnology and Bioprocess Engineering Vol.20, P.971-979
154 Yeounjoo Ko, Somasundar Ashok, Eunhee Seol, Ainala Satish Kumar, Sunghoon Park*, 2015
“Deletion of putative oxidoreductases from Klebsiella pneumoniae J2B could reduce 1,3-propanediol during the production of 3-hydroxypropionic acid from glycerol”
Biotechnology and Bioprocess Engineering, Vol.20, P.834-843
153 Shengfang Zhou, Satish Kumar Ainala, Eunhee Seol, Trinh Thi Nguyen, Sunghoon Park*, 2015
“Inducible Gene Expression System by 3-Hydroxypropionic Acid”
Biotechnology for Biofuels, Vol. 8, P.169-176
152 Sunghoon Park, Wolfgang Schumann*, 2015
“Optimization of the Secretion Pathway for Heterologous Proteins in Bacillus subtilis”
Biotechnology and Bioprocess Engineering, Vol.20, P.623-633
151 Satish Kumar Ainala, Eunhee Seol, Sunghoon Park *, 2015
“Complete genome sequence of novel carbon monoxide oxidizing bacteria Citrobacter amalonaticus Y19, assembled de novo”
Journal of Biotechnology, Vol. 211, P.79–80
150 Yan Zhang, Somasundar Ashok, Eunhee Seol, Satish Kumar Ainala, Sun-Gu Lee, Bharat Madan, Jian-He Xu, Sunghoon Park*, 2014
“NADH-dependent lactate dehydrogenase from Alcaligenes eutrophus H16 reduces 2-oxoadipate to 2-hydroxyadipate”
Biotechnology and Bioprocess Engineering, Vol.19, P.1048-1057
149 Yan Zhang, Jiang Pan, Zheng-Jiao Luan, Guo-Chao Xu, Sunghoon Park, Jianhe Xu, 2014
"Cloning and characterization of a novel esterase from Rhodococcus sp. for highly enantioselective synthesis of a chiral cilastatin precursor"
Appl. Eviron. Microbiol., Vol.80(23), P. 7348-7355
148 Balaji Sundara Sekar, Subramanian Mohan Raj, Eunhee Seol, Satish Kumar Ainala, Jungeun Lee, Sunghoon Park*, 2014
“Cloning and functional expression of citrobacter amalonaticus Y19 carbon monoxide dehydrogenase in Escherichia coli”
International J. of Hydrogen Energy, Vol.39, P.15446-15454
147 Yeounjoo Ko, Somasundar Ashok, Satish Kumar Ainala, Mugesh Sankaranarayanan, Ah Yeong Chun, Gyoo Yeol Jung, Sunghoon Park*, 2014
“Coenzyme B12 can be produced by engineered Escherichia coli under both anaerobic and aerobic conditions”
Biotechnology Journal, Vol.9(12), P.1526-1535
146 Ah Yeong Chun, Liang Yunxiao, Somasundar Ashok, Eunhee Seol, Sunghoon Park*, 2014
“Elucidation of toxicity of organic acids inhibiting growth of Escherichia coli W”
Biotechnology and Bioprocess Engineering, Vol.19, P.858-865
145 Eunhee Seol, Satish Kumar Ainala, Balaji Sundara Sekar, Sunghoon Park *, 2014
“Metabolic engineering of Escherichia coli strains for co-production of hydrogen and ethanol from glucose”
International J. of Hydrogen Energy, Vol. 39(33), P.19323-19330
144 Satish K Ainala, Eunhee Seol, Balaji S Sekar, Sunghoon Park *, 2014
“Improvement of Carbon Monoxide-dependent Hydrogen Production Activity in Citrobacter
amalonaticus Y19 by Over-expressing the CO-Sensing Transcriptional Activator, CooA”
International J. of Hydrogen Energy Vol.39, P.10417-10425
143 Mugesh Sankaranarayanan, Somasundar Ashok, Sunghoon Park*, 2014
“Production of 3-hydroxypropionic acid from glycerol by acid tolerant Escherichia coli”
Journal of Industrial Microbiology & Biotechnology Vol.41(7), P.1039-1050
142 Meetu Durgapal, Vinod Kumar, Taek Ho Yang, Hee Jong Lee, Doyoung Seung, Sunghoon Park*, 2014
“Production of 1,3-propanediol from glycerol using the newly isolated Klebsiella pneumoniae J2B”
Bioresource Technology Vol.159, P.223-231
141 Shengfang Zhou, Somasundar Ashok, Yeounjoo Ko, Dong Myung Kim, Sunghoon Park*, 2014
“Development of a deletion mutant of Pseudomonas denitrificans that does not degrade 3-hydroxypropionic acid”
Applied Microbiology and Biotechnology Vol.98, P.4389–4398
140 Philah Lee, Subramanian Mohan Raj, Shengfang Zhou, Somasundar Ashok, Sunghoon Park*, 2014
“3-Hydroxyisobutyrate Dehydrogenase-I from Pseudomonas denitrificans ATCC 13867 Utilizes 3-Hydroxypropionic Acid”
Biotechnology and Bioprocess Engineering Vol.19, P.1-7
139 Biyu Kang, Xuehong Zhang, Zhenqiang Wu, Zhilong Wanga, Sunghoon Park, 2014
“Production of citrinin-free Monascus pigments by submergedculture at low pH”
Enzyme and Microbial Technology Vol.55, P.50-57
138 Vinod Kumar, Somasundar Ashok, Sunghoon Park*, 2013
“Microbial production of 3-HP from renewable sources: A green approach as an alternative to conventional chemistry”
Wiley Periodicals, Inc. Book Chapter, 2013
137 Liu Yang PNU and ECUST, Ashok, Seol, Jie Bao at ECUST, S. Park, 2013
“Comparison of three Pediococcus strains for lactic acid production from glucose in the presence of inhibitors generated by acid hydrolysis of lignocellulosic biomass”
Biotechnology and Bioprocess Engineering Vol.18, P.1192-1200
136 Su-Jin Park, Hai-Bo Liu, Sunghoon Park, Joon-Hee Lee*, 2013
“Modulation of QscR, a quorum sensing receptor of Pseudomonas aeruginosa, by truncation of a signal binding domain”
RESEARCH IN MICROBIOLOGY Vol.164(5), P.375-381
135 Shengfang Zhou, Christy Catherine, Chelladurai Rathnasingh, Somasundar Ashok, Sunghoon Park, 2013
“Production of 3-hydroxypropionic acid from glycerol by recombinant Pseudomonas denitrificans”
Biotechnology and Bioengineering, Vol.110(12), P. 3177-3187
134 Satish Kumar Ainala, Somasundar Ashok, Yeounjoo Ko, Sunghoon Park, 2013
“Glycerol assimilation and production of 1,3-propanediol by Citrobacter amalonaticus Y19”
Appl Microbiol Biotechnol, Vol.97, P.5001-5011
133 Vinod Kumar, Somasundar Ashok, Ritam Sarkar, Sunghoon Park*, 2013
“Recent advances in biological production of 3-hydroxypropionic acid”
Biotechnology Advance, Vol.31(6), P.945-961
132 Shengfang Zhou, Subramanian Mohan Raj, Somasundar Ashok, Selvakumar Edwardraja, Sun-gu Lee, Sunghoon Park*, 2013
“Cloning, expression and characterization of 3-hydroxyisobutyrate dehydrogenase from Pseudomonas denitrificans ATCC13867”
PLoS ONE, Vol.8(5) P.62666
131 Satish Kumar Ainala, Ashok Somasundar, Sunghoon Park*, 2013
"Complete Genome Sequence of Pseudomonas denitrificans ATCC 13867"
Genome Announcements Vol.1(3) P.257-13
130 Mariadhas Valan Arasu, Ritam Sarkar, Balaji Sundara Sekar, Vinod Kumar, Chelladurai Rathnasingh, Jin-dal-rae Choi, Hyohak Song, Doyoung Seung, Sunghoon Park*, 2013
“Isolation of a novel Pseudomonas species SP2 which produce vitamin B12 under aerobic condition”
Biotechnology and Bioprocess Engineering, Vol.18, P.43-52
129 Vinod Kumar, Mugesh Sankaranarayanan, Meetu Durgapal, Shengfang Zhou, Yeounjoo Ko, Somasundar Ashok, Ritam Sarkar, Sunghoon Park*, 2013
“Simultaneous production of 3-hydroxypropionic acid and 1,3-propanediol from glycerol using resting cells of the lactate dehydrogenase-deficient recombinant Klebsiella pneumoniae overexpressing an aldehydede hydrogenase”
Bioresourse Technology, Vol.135, P.555-563
128 Somasundar Ashok, Mugesh Sankaranarayanan, Yeounjoo Ko, Kyeung-Eun Jae, Satish Kumar Ainala, Vinod Kumar, Sunghoon Park*, 2013
“Production of 3-hydroxypropionic acid from glycerol by recombinant Klebsiella pneumonia ΔdhaTΔyqhD which can produce vitamin B12 naturally”
Biotechnology and Bioengineering, Vol.110(2), P.511-524
127 Somasundar Ashok, Subramanian Mohan Raj, Yeounjoo Ko, Mugesh Sankaranarayanan, Shengfang Zhou, Vinod Kumar, Sunghoon Park*, 2013
"Effect of puuC overexpression and nitrate addition on glycerol metabolism and anaerobic 3-hydroxypropionic acid production in recombinant Klebsiella pneumoniae ∆glpK∆dhaT"
Metabolic Engineering, Vol. 15 P. 10~24
126 Chelladurai Rathnasingh, Duk-Ki Kim, Hyohak Song, Hee Jong Lee, Doyoung Seung, Sunghoon Park*, 2012
“Isolation and characterization of a new mucoid-free Klebsiella pneumoniae strain for 2,3-butanediol production”
African Journal of Biotechnology, Vol. 11(51) P. 11252~11261
125 Vinod Kumar, Mugesh Sankaranarayanan, Kyeung-eun Jae, Meetu Durgapal, Somasundar Ashok, Yeounjoo Ko, Ritam Sarkar, Sunghoon Park*, 2012
"Co-production of 3-hydroxypropionic acid and 1,3-propanediol from glycerol using resting cells of recombinant Klebsiella pneumoniae J2B strain overexpressing aldehyde dehydrogenase"
Appl Microbiol Biotechnol, Vol. 96 P. 373~383
124 Eunhee Seol, Younga Jang, You-Kwan Oh, Sunghoon Park*, 2012
"Engineering of formate-hydrogen lyase gene cluster for improved hydrogen production in Escherchia coli"
International journal of hydrogen energy, Vol. 37 P. 15045~15051
123 Yeounjoo Ko, Somasundar Ashok, Shengfang Zhou, Vinod Kumar, Sunghoon Park*, 2012
"Aldehyde dehydrogenase activity is important to the production of 3-hydroxypropionic acid from glycerol by recombinant Klebsiella pneumoniae "
Process Biochemistry, Vol. 47 P. 1135~1143
122 Jungeun Lee, Eunhee Seol, Gurpreet Kaur, You-kwan Oh, Sunghoon Park*, 2012
"Hydrogen production from C1 Compounds by a novel marine hyperthermophilic bacterium Thermococcus onnurineus NA1"
International journal of hydrogen energy, Vol. 37 P. 11113~11121
121 Seohyoung Kim, Dongping Lu, Sunghoon Park, Guangyi Wang, 2012
"Production of hydrogenases as biocatalysts"
International journal of hydrogen energy, Vol. 37 P. 15833~15840
120 Chelladurai Rathnasingh, Subramanian Mohan Raj, Youjin Lee, Christy Catherine, Somasundar Ashok, Sunghoon Park*, 2012
"Production of 3-hydroxypropionic acid via malonyl-CoA pathway using recombinant Escherichia coli strains"
Journal of Biotechnology, Vol. 157(4) P. 633-640
119 Eunhee Seol, Ayyachamy Manimaran, Younga Jang, Seohyoung Kim, You-Kwan Oh, Sunghoon Park*, 2011
"Sustained hydrogen production from formate using immobilized recombinant Escherichia coli SH5"
International Journal of Hydrogen Energy, Vol. 36 P.8681~8686
118 Somasundar Ashok, Subramanian Mohan Raj, Chelladurai Rathnasingh, Sunghoon Park*, 2011
"Development of recombinant Klebsiella pneumoniae △dhaT strain for the co-production of 3-hydroxypropionic acid and 1,3-propanediol from glycerol”
Applied Microbiology and Biotechnology, Vol. 90 P. 1253-1265
117 You-Kwan Oh, Eun-hee Seol, Soonchul Park, Sunghoon Park*, 2011
"Decolorization of synthetic dyes by Citrobacter amalonaticus Y19”
Journal of the Taiwan Institute of Chemical Engineers, Vol. 42 P. 492~497
116 You-Kwan Oh, Eun-hee Seol, Soonchul Park, Sunghoon Park*, 2011
"Development and Comparison of Whole Cell Assay Systems for Quorum Sensing Inhibitors Based on TraR, LasR and QscR"
Journal of Biomedical Screening, Vol. 16(9) P. 986~994
115 Valan Arasu, Vinod Kumar, S. Ashok, C. Rathnasingh, Hyohak Song, Hee Jong Lee, Doyoung Seung, Sunghoon Park
"Isolation and characterization of the new Klebsiella pneumoniae J2B strain showing improved growth characteristics with reduced lipopolysaccharide formation"
Biotechnology and Bioprocess Engineering, Vol. 16 P. 1134~1143
114 You-Kwan Oh, Subramanian Mohan Raj, Gyoo Yeol Jung, Sunghoon Park*, 2011
"Current status of the metabolic engineering of microorganisms for biohydrogen production”
Bioresource Technology, Vol. 102(18) P. 8357~8367
